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Some children are born with defective immune systems and have problems dealing with infections, or develop abnormal responses causing inflammation and autoimmunity. The genetic basis of many of these conditions can now be determined using a combination of gene screening tests and assays to determine immune cell phenotype and function

Immunology

 

Bone & Blood Stem Cell Transplants

 

Where defects of the immune system lead to serious complications, bone marrow transplantation is often considered. Stem cells can be collected from bone marrow, from peripheral blood and from umbilical cord blood. A well matched donor (HLA matched sibling) is the preferred choice, but with improved techniques, unrelated donor and mismatched transplants are also widely used. We are developing approaches to limit complications such as graft versus host and disease and virus infections.
Contact
 
Please direct clinical queries 
through hospital NHS email
 
Email: 
Waseem.Qasim@Gosh.NHS.UK
​
Great Ormond Street Hospital
London
WC1N 3JH
 

CAR T cells

 

CAR T cells have been developed from bench to bedside at GOSH. Trials are underway for children with hard to treat leukaemia, with our group addressing unmet needs where standard treatments haven't been sufficient. 
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